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Why cefepime is better than cefoperazone and more beneficial in patients. Omicron’s 50 genetic changes include more than 30 on the spike protein ,the exposed part of the virus that binds with human cells with 70 strains. Effectiveness of current treatments :Corticosteroids and IL6 Receipt or Blockers will still be effective for managing patients with severe COVID-19.Other treatments will be assessed to see if they are still as effective given the changes to parts of the virus. Reserve the Carbapenem group and switch to Cephalosporin drugs. 1) 4th Generation Cephalosporin 2)) 2:1combination,Efficecy is high with Sulbactum combination, less Nephrotoxicity Drug penetration is high , No Dosage adjustment required, Hospital staying day decrease, less chance hospital acquired infection 3) L-arginine maintain the PH level of body and drugs. 4) Zwitter ion have 2group strains and trans -Cefepime is cover both hence Cefoperazone cover only Strains group. 5) for SPICE group the drugs of choice is CEFTECT SB because Cefoperazone cover only Esbls & Ceftect sb cover Esbls & Ampc or all other spice group of bacteria 6) pseudomonas coverage of cefepime is higher than compare to all other Cephalosporin drugs.
